Drs. Gerstenberger and Ruh develop a formula based on the composition of human milk.

Extensive clinical studies of the formula, named SMA (Synthetic Milk Adapted), at the Babies' Dispensary and Children's Hospital in Cleveland establish it as a successful feeding alternative for infants.

First commercial production and distribution of SMA signal the birth of the US infant formula industry.

Shipments of SMA to England and the Philippines are the forerunners of today's worldwide distribution.

Carotene is added to SMA in amounts equal to those in human milk. The company becomes the world's major supplier of carotene.

Iron is added in an amount sufficient to satisfy the infant's requirements.

Improvements are made in labeling and packaging. The SMA label is first in the industry to carry an expiration date.

Wyeth develops the first commercially available infant formula for healthy term infants from birth onwards with a whey-to-casein ratio of 60:40, similar to that of mature human milk. The process, developed by Wyeth, demineralizing whey makes it possible to increase the whey content of the formula without increasing the load on the kidneys, making it easier on the infant's system.

The launch of Wyeth's follow-on formula, PROMIL GOLD, helps ensure good nutrition during the weaning period and beyond.

Nucleotides are added to Wyeth infant formula. Five important nucleotides found in human milk were identified and added to Wyeth's infant formula. Wyeth formula is fortified with nucleotides which help enhancing infants' immunity.

Wyeth launches Progress. An iron-rich, high-energy, cow's milk-based supplement, Progress, is formulated for children between the ages of one and three years.

Wyeth's AR, an antiregurgitation formula, is launched in several countries around the world.

Wyeth introduces a lactose-free (LF) formula for babies with lactose intolerance.

Wyeth launches the first in its GOLD line, a premium, whey-dominant infant formula enriched not only with preformed AA and DHA derived from pure vegetable sources, but also with physiologic amounts of five nucleotides, natural mixed carotenoids, selenium, and iron.

Wyeth launches Promise, a growing-up formula specifically formulated for children from three years of age onwards to provide a healthy foundation for nutrition.

Wyeth launches PROMIL GOLD, the follow-on formula for infants 6 to 12 months of age is the first of its kind to be fortified with both AA and DHA, long-chain polyunsaturated fatty acids derived from pure vegetable sources.

Wyeth introduces its AA- and DHA-fortified Progress Gold for children 1 to 3 years old.

The first and only infant formula rich in alpha-lactalbumin (alpha-protein) is the latest innovation in first-age infant formula GOLD from Wyeth Nutrition. It has the most physiologic profile of any infant formula in the world.

Wyeth's HA, a partially hydrolyzed Whey protein-based formula for infants at risk for developing allergy-related feeding problems, is introduced.

Wyeth introduces its AA- and DHA-fortified Promise Gold formulation, for children 3 years and onwards.

Wyeth Nutrition becomes the first nutritional company to globally launch the addition of lutein simultaneously across the Wyeth GOLD range, including PROMIL GOLD, Progress GOLD, and Promise GOLD.

After Pfizer's acquisition of Wyeth, the former nutrition business of Wyeth becomes Pfizer Nutrition, one of Pfizer's nine Business Units.

Pfizer Nutrition launched PE GOLD, the nutritional formula for picky eating children aged 1 year old and above, containing 40 nutritional components found in 7 major food categories and specifically supplementing the 7 at risk nutrients that picky eating young children might be lacking of.

In accordance with scientific advancement and new recommendations from key opinion leaders, Pfizer Nutrition launched the advanced all-round nutrition formulation, readjusting macro- and micro-nutrient levels to closely match the nutritional requirement of children at different age ranges.

Pfizer Nutrition launches Enercal Plus, a milk- and soy-based supplement for adults, in a totally new look. It is a remarkable milestone for the company to step into the market of adult supplement, aiming to help provide product users with all-round nutrition.

With the commitment to innovation, Pfizer Nutrition launches ILLUMA. By understanding babies' natural nutritional needs, ILLUMA incorporates the innovative "Human Affinity Formula" which follows nature. It contains sn-2 Palmitate, a breakthrough body-friendly molecular structure.

IMA-EM-100-AUG-12

Nestle acquires Pfizer Nutrition and makes it Wyeth Nutrition, which continues to offer safe, quality and scientifically-designed nutritional products to improve nutrition and wellness for young children, women and adults.